The 35% response rate in WHO grade III astrocytoma (anaplastic astrocytoma) ( Yung et al , 1999 ) in comparison to 6–8% response rate in grade IV tumours (glioblastoma multiforme) ( Yung et al , 2000 ; Brada et al , 2001 ) suggests a possible trend of increasing efficacy in lower grade tumours previously noted for nitrosourea-containing chemotherapy ( Rajan et al , 1994 ).
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Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy.
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