The new finding of our study, which focused on the co-influence of biomechanical loading in subjects with leptin deficiency, is that it confirmed the presence of leptin as the pre-condition for a positive trend between loading and bone mass, in contrast to what has been reported in the literature so far 44 , 56 .
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Differences in trabecular bone of leptin-deficient ob/ob mice in response to biomechanical loading.
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