Barely Significant
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Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro.

J Inflamm (Lond) · 2008 · PMC2438359 · PMID 18554383

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highly significantP < 0.05actually significant
In contrast, incubation of COX-2 enzyme with pre-supplementation plasma inhibited the enzyme activity by 12.27 ± 4.79% ( P > 0.05 compared to control) but incubation with post supplementation plasma inhibited the COX-2 activity by 38.8 ± 9.59% and this inhibition of COX 2 enzyme activity was statistically highly significant ( P < 0.05).

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