These analyses showed a small but significant increase in axonal outgrowth upon APLP1 knock down (an increase with APLP2 knock down failed to reach significance) and significant decreases in the number of primary neurites with knock down of APLP1 or APLP2, relative to control GFP electroporations (Figure 2j, k ).
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Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.
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