Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.

Following a procedure similar to that used to build the reported model, simulated multi-marker models containing SNPs from randomly chosen genes in a genome wide PD dataset produced P -values that were highly significant and indistinguishable from similar models where disease status was permuted (3.13×10 −23 to 4.90×10 −64 ), demonstrating the potential for overfitting in the model building process.

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No significant association was observed in the Celera sample set at the 0.05 level, but there was a borderline significance in the Thessaly sample set ( Table 2 ).

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