Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.

PLoS Pathog · 2008 · PMC2444047 · PMID 18636106

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a nonsignificant trendno p-value reported

In our previous study [28] , we observed a nonsignificant trend for more efficient MHC-I downmodulation by CD4high Nefs.

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highly significantno p-value reported

Since both represent T cell activation markers, we observed a highly significant correlation between the levels of IL-2R and PD-1 expression on HIV-1 infected PBMCs ( Figure 6C ).

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failed to reach significanceno p-value reported

The same trend was observed for modulation of MHC-I by Nef but failed to reach significance ( Figures 3C , S5A ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.