Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family.

A highly significant difference was identified with those born after 1960 having a breast cancer risk to 40 years of age of 40% compared to only 7.5% for those with a year of birth between 1900 and 1920 (Figure 3 : p < 0.00001).

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