Enzymatic properties of the neuraminidase of seasonal H1N1 influenza viruses provide insights for the emergence of natural resistance to oseltamivir.

PLoS Pathog · 2008 · PMC2453323 · PMID 18654625

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likely to be significantno p-value reported

Substitutions in the vicinity of the substrate binding site may influence the affinity of the neuraminidase for its substrate, whereas remote substitutions in the ectodomain are less likely to be significant.

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