Solitary skull metastasis as initial manifestation of hepatocellular carcinoma.

World J Surg Oncol · 2008 · PMC2467423 · PMID 18570669

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an increasing trendno p-value reported

Although the incidence of bone metastases in HCC has been described as very low in autopsy studies, an increasing trend has been reported recently [ 4 , 5 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.