Effect of combination therapy with a calcium channel blocker and an angiotensin-converting enzyme inhibitor on renal hypertrophy and urinary albumin excretion in diabetic rats.

After 9 weeks, UAE was re- duced to the nondiabetic level in nitrendipine-treated rats, and was significantly different from placebo-treated diabetic ani- mals(P < .05).Combiningenalaprilandnitrendipinetreatment showed no further reduction in UAE compared to monotherapy with nitrendipine, and monotherapy with enalapril failed to re- vealasignificantreductioninUAEcomparedtoplacebo-treated diabetic animals, although a tendency toward a lower UAE was observed (P > .05). In the intervention trial, a highly significant increase in UAE was observed after 3 months of untreated diabetes compared to the nondiabetic condition (P < .001) (Figure 3B).

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