Barely Significant
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The concept of translocational regulation.

J Cell Biol · 2008 · PMC2483521 · PMID 18644895

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highly significantno p-value reported
From a physiological standpoint, small changes (e.g., twofold or less) of key secretory and membrane proteins, such as hormones and surface receptors, can be highly significant but difficult to study.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.