A variant in the sonic hedgehog regulatory sequence (ZRS) is associated with triphalangeal thumb and deregulates expression in the developing limb.

Hum Mol Genet · 2008 · PMC2486440 · PMID 18463159

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hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP = 1.05 × 10 −6actually significant

The difference in occurrence of the 295C allele in probands with triphalangeal thumb (3/5), compared with controls (0/381), was highly significant ( P = 1.05 × 10 −6 , Fisher's exact test).

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