I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels.

Similarly, we report here that deletion of this D1–2 proximal region in both Ca v 3.1 and Ca v 3.3 channels yields large and highly significant alterations in activation and inactivation properties (see Table 1 ), which fully mimics removal of the gating brake locus in Ca v 3.2 [4] .

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