The structural equation model revealed a highly significant association between the genotype and LDL-C as well as between LDL-C and CAD risk, but the association between rs2228671 and the risk of CAD was abolished (OR 0.99, 95 % CI [0.85–1.16], p = 0.95, Fig. 5 ).
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Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
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