a trend toward significancep = 0.087
The reduction in mean 24-hour DBP with olmesartan (8.5 mmHg) was significantly greater than reductions with losartan and valsartan (6.2 and 5.6 mmHg, respectively, p < 0.05) and showed a trend toward significance compared with the reduction in DBP with irbesartan (7.4 mmHg; p = 0.087).