Identifying patterns in treatment response profiles in acute bipolar mania: a cluster analysis approach.

Interestingly, the previous number of manic episodes had a marginally significant but positive effect on early discharge (adjusted OR = 1.08, p = .067), which suggests that while early discharge was driven by mania improvement during the first 7 days, the patient's history of recurrence of mania was not considered in making early discharge decisions.

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Specifically, when using orthogonal polynomials, the coefficients have the following natural interpretation, independently of other terms included: the coefficient at linear term represents an overall trend in the outcome profile, the coefficient at quadratic term is the rate of change in the expected outcome at time t, and so on [ 11 ].

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