highly significantp<0.001
Twenty four hour hypoxia treatment of 24 and 48 hpf embryos resulted in 3.4∼5.5 fold, highly significant increases (p<0.001) in IGFBP-1a mRNA levels and modest but statistically significant increases in IGFBP-1b mRNA levels (2.1 and 2.6 fold increases, p<0.01∼0.05).