Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin.

A marginally significant correlation was found for nucleotide diversity between T0 and T1/T2 samples from each patient ( r = 0.396, P = 0.056).

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Furthermore, we have shown that there is not a single, common pattern in the variation of the nucleotide diversity during the antiviral treatment, especially in the NS5A region, although the E1-E2 region presents a slight trend to increase genetic diversity ( Figure 1 and Tables 1 and 2 ).

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