highly significantp≤5.42×10 −7
This effect was highly significant for both deletion and mutation of these sequences within both elements, albeit more severe for Sox10 -MCS7 (≥80% reduction in enhancer activity, p≤5.42×10 −7 ) than for Sox10 -MCS4 (50–80% reduction in activity, p≤2.11×10 −7 ).