Does codon bias have an evolutionary origin?

Theor Biol Med Model · 2008 · PMC2519059 · PMID 18667081

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highly significantno p-value reported

Numerous, statistically highly significant, internal correlations were found among codons and the nucleic acids they comprise.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.