Transforming growth factor beta production is inversely correlated with severity of murine malaria infection.

berghei –infected mice are treated with rTGF-β, there is a highly significant decrease in circulating levels of TNF-α (Fig. 5 a ; t >4.8, df = 8, P <0.001 at days 3, 7, and 10), and when mice are given anti–TGF-β antibody, serum TNF-α levels are significantly higher (day 7 after infection, control mice, mean TNF-α = 5.4 ± 0.5 ng/ml; anti–TGF-β mice, mean = 9.15 ± 0.92 ng/ml; t = 7.92, df = 7, P <0.0001).

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