Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array.

BMC Genomics · 2008 · PMC2527337 · PMID 18655706

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closest p · 0.0× alpha

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highly significantp = 2.5e-10actually significant

This bias towards inactivation is highly significant (p = 2.5e-10 in a chi-squared test), indicating that more promoters are inactivated by E2 than are activated, which supports the previous report about estrogen-mediated early-down regulated genes [ 43 ].

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