Variants in iron metabolism genes predict higher blood lead levels in young children.

Environ Health Perspect · 2008 · PMC2535632 · PMID 18795173

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

marginally significantp = 0.06so close (0.05 < p ≤ 0.1)

There was a statistically significant unadjusted gene-by-gene interaction (β unadj = 0.37, p = 0.02) between the HFE and TF genotypes and, when adjusted for maternal blood lead level at delivery and child’s concurrent anemia status, this interaction term was marginally significant (β adj = 0.31, p = 0.06) (data not shown).

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borderline significantp = 0.08so close (0.05 < p ≤ 0.1)

However, in the longitudinal analysis (using repeated measures of blood lead at 24, 30, 36, 42, and 48 months of age) adjusting for covariates (maternal blood lead level at delivery and child’s concurrent anemia status), the relationship between HFE genotype and blood lead was statistically significant (β = 0.11, p = 0.04), and the relationship between TF genotype and blood lead was borderline significant (β = 0.10, p = 0.08) ( Table 5 ).

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