Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: the effect of water and timing of meal intake on oral delivery of Salmon Calcitonin.

The effect of water volume was statistically highly significant irrespective of post-meal timing (10, 30 and 60 minutes post-meal time: p < 0.001).

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The delayed intake of water significantly increased sCT when comparing 10 and 60 minutes, and was borderline significant at 30 minutes compared to that of 10 minutes.

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