'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.

Background The first genome wide association study (GWA) for early onset extreme obesity recently revealed highly significant association of six strongly linked SNPs in intron one of FTO with obesity [ 1 ].

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Despite a small trend of the risk A-allele carriers to lose less weight than the non-risk allele carriers, the follow-up study comprising 207 German overweight and obese individuals revealed no significant association of the rs9939609 genotype with body weight loss due to an obesity intervention program.

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