Interventions reported in these cases included corticosteroids and intravenous immunoglobulin (IVIG) as well as fresh frozen plasma, platelets and red blood cell transfusion, plasmapheresis, vitamin K, recombinant factor VIIa (rFVIIa), cyclophosphamide, and/or rituximab; thus, the potential economic impact of an induced coagulopathy associated with exposure to bovine thrombin may be significant.
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