Retinal afferent ingrowth to neocortical transplants in the adult rat superior colliculus is due to the regeneration of damaged axons.

Intensely labeled retinofigal fibers in the small zone of traumatic reaction rostral to a transplant, 30 days after lesion/TRT surgery B. Small ncuroma-likc tangled masses of HRP labeled rctinofugal fibers (n) are present in the ztr proximal to a region of apparently vell integrated imcrface where blood vessels are present, 90 days after transverse lesion/transplant surgery. the optic layer interface area across which retinal afferents penetrated corresponded in every case to the zone of traumatic reaction in the optic layers, the highly significant (r=0.92) positive correlation between this interface area and the volume of transplant innervation indicates that the magnitude of retinal afferent ingrowth was highly dependent upon the magnitude of retinofugal axonal damage at the transplantation site.

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