PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.

Diabetes · 2008 · PMC2570415 · PMID 18647954

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a nonsignificant trendno p-value reported

Although these SNPs only showed a nonsignificant trend in another 500 K GWA study of Scandinavians (Diabetes Genetics Initiative [DGI]) ( www.broad.mit.edu/diabetes ), they were significantly associated with type 2 diabetes in a meta-analysis of subjects of European descent (Diabetes Genetics Replication and Meta-analysis [DIAGRAM]) ( 20 ).

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