PYY-positive endocrine cells are often surrounded by Y 1 -immunoreactive epithelia and nerve fibers but are themselves Y 1 -negative [26] ; thus a paracrine rather than an autocrine action for PYY is likely to be significant in human colon.
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Endogenous PYY and NPY mediate tonic Y1- and Y2-mediated absorption in human and mouse colon.
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