Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity.

J Med Chem · 2008 · PMC2574667 · PMID 18533711

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highly significantno p-value reported

Because of the absence of iNOS, stimulation of the macrophages with interferon (IFN)-γ plus tumor necrosis factor (TNF) had only a very weak antileishmanial effect, as seen before.( 14 ) In contrast, addition of 9a or 9b led to a highly significant decrease in the number of intracellular parasites, with 9a being more potent than 9b .

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of borderline significanceno p-value reported

Neither of the fucose derivatives had any perceivable effect on the parasite burden of these cells, and only one of the mannosides ( 5a ) showed any activity, that being of borderline significance.

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