Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.

Hum Mol Genet · 2008 · PMC2581433 · PMID 18723524

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highly significantno p-value reported

Using logistic regression analyses of rs5848, we showed a highly significant association of rs5848 with FTLD-U ( P adjusted = 0.003), resulting from an increase in the TT genotype frequency of rs5848 in FTLD-U patients (25.4%) compared with control individuals (9.9%) (Table 3 ).

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