Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Of particular interest were Pip2a–PNADMD- and Pip2b–PNADMD-treated mdx muscles which showed a highly significant increase ( P < 0.05) in the number of dystrophin-positive myofibres compared with those treated with PNA alone, Pip1 and RXR4–PNA conjugates compared with age-matched control mdx mice ( Figure 5 b).

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