Hypermutable non-synonymous sites are under stronger negative selection.

PLoS Genet · 2008 · PMC2583910 · PMID 19043566

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highly significantno p-value reported

This difference is insignificant for transversions and highly significant for transitions, according to the χ 2 test ( p = 2.8·10 −16 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.