Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration.

PLoS One · 2008 · PMC2585793 · PMID 19048105

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0650

boldest claim

The sentences

highly significantp <0.001actually significant

Interaction analyses In the logistic regression modelling, we found highly significant ( p <0.001) additive gene effects for the LOC387715 and CFH loci, both having approximately the same effect size ( Table 3 ).

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of borderline significancep = 0.054so close (0.05 < p ≤ 0.1)

Possible explanations for this complexity in the logistic regression modelling showed up in further stratified analyses, where we found out that i) ever-smoker women had 4.68-fold (95%CI 1.95–14.12, p = 3.60×10 −4 ) risk of AMD when compared to never-smoker women, whereas in men the odd's ratio was smaller (OR = 2.57) and of borderline significance (95%CI 0.99–6.86, p = 0.054).

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borderline significancep = 0.065so close (0.05 < p ≤ 0.1)

The sex×smoking interaction term preserved borderline significance (now, p = 0.065) ( Table 3 ).

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