Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans.

The algorithm identified acetaldehyde and ethanol to be highly significant nodes (among the ten most regulated metabolites, p<0.01) when grown on glucose (acetyl-CoA was not found as a significant reporter metabolite even though all reactions connecting it to the TCA were induced on glucose, since it is involved in a large number of fatty acid reactions with no significant regulation).

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