A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation.

The functional significance of the His 452 Tyr substitution was better assessed by linear regression analysis, weighted for ADP-induced platelet aggregation; by this procedure, it was confirmed at a highly significant level that the His 452 Tyr substitution of the 5-HTR 2A dampened platelet aggregation in response to 5-HT (Figure 2 , P = 0.003).

also in 132,142 other papers