Initiation and promotion in cancer formation: the importance of studies on intercellular communication.

However, when followed by croton oil in multiple treatments many skin tumors resulted. Their report was almost immediately repeated and confirmed by Berenblum and Haran who reported two years later [35]: These results support the findings of Salaman and Roe (1953) that urethane, itself non-carcinogenic for mouse skin, can induce the initiating phase of carcinogenesis in that tissue. These two reports are extremely significant because they show that promotion can be the decidng factor for cancer production.

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