The effect of IA-2 + serum samples in enhancing antigen presentation of IA-2ic-HA 307–319 was seen in samples from more than one patient with IA-2 autoantibodies and was highly significant ( Fig. 6 D and E ).
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Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.
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