In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.

The C-terminal 200 amino acid stretch of the MT containing sequence from bleomycin [ 35 ], nodularin and melithiazol also showed highly significant alignments (Figure 8b ) with the structural subdomain (Figure 4 ) of the recently elucidated structure of KR from erythromycin PKS.

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