Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

However, we observed an overall trend of weaker effect size in JHS-AFR than JHS-EUR, with some marked differences such as rs662799 in ApoA5 , suggesting that many of these “index” SNPs are merely tagging causal alleles, with the effect size depending on the correlation between the index SNP and the causal SNP(s).

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We used precise individual ancestry estimates to show a highly significant association of individual African/European ancestry with serum TG and HDL-C, suggesting strongly that genetic factors account for at least some of the epidemiologically observed interethnic differences.

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