Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis.

Do the genomic regions bound in both human and mouse correspond to regulatory regions in the vicinity of active transcription (that is, in close proximity to shared H3K4me3 peaks), whereas uniquely bound regions do not? In other words, do conserved binding events represent the functional sites? If this is the case, it suggests that once 'functional' cis -binding events are distilled from non-functional ones, there may be significant conservation in cis -regulatory networks.

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