Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death.

PLoS Pathog · 2009 · PMC2629126 · PMID 19197351

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Marginal loss of control in cells deficient in Irga6 (IIGP1) contrasts with highly significant inhibition in IFNγ-treated wild-type cells expressing a dominant negative form of Irga6 [17] , presumably as a result of the high level of interactivity recently documented between the IRG proteins [20] .

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