Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML).

PLoS Genet · 2009 · PMC2629573 · PMID 19197354

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highly significantno p-value reported

In contrast, for VP1 sequences isolated from PML patients, allowing codons to evolve under positive selection resulted in a highly significant increase in the model likelihood ( Table 1 ).

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