Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice.

Also, a highly significant correlation between dermal fat thickness away from tumors and the skin tumor multiplicity was found across individual mice [ 18 , 19 ], suggesting that the exercise-induced reduction in dermal fat contributed to the inhibition of skin tumorigenesis.

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Since our prediction was that exercise would reduce tumor formation, the one-tailed Student's t -test was used as a back-up only if the two-tailed t -test showed borderline significance.

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