A modeling study by response surface methodology and artificial neural network on culture parameters optimization for thermostable lipase production from a newly isolated thermophilic Geobacillus sp. strain ARM.

With very small "model P-value" (< 0.0001) and large "lack of fit P-value" (0.6932) from the analysis of ANOVA and a suitable coefficient of determination (R 2 = 0.9998) and adjusted coefficient of determination (R 2 adjusted = 0.999), the modified cubic polynomial model was highly significant and sufficient to represent the actual relationship between the response and the significant variables (Table 2 ).

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