Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial.

The risk reduction was statistically definite only in the 3000 patients who were still not at such a clinic after more than 6 h; half of these patients were still not there after more than 15 h, giving the trial treatment enough time to affect the progression of the disease substantially and thereby achieve a highly significant reduction in death or permanent disability.

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