mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue.

In addition, the MCM2 expression level increased with increasing grade of dysplasia, with a highly significant difference between the mild and moderate epithelial dysplasia ( p < 0.001), between the mild and severe epithelial dysplasia ( p = 0.000), and between the moderate and severe epithelial dysplasia ( p < 0.001).

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