Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli.

However, after two cycles of drug administration, the cisplatin group exhibited highly significant thermal hyperalgesia compared to the vehicle group, and this heat hypersensitivity persisted with a 46% decrease in tail flick latency at week four (1.83 ± 0.23 s vs 3.39 ± 0.19 s, *** P < 0.05, ANOVA), and a 36% decrease in tail flick latency at week six (2.15 ± 0.14 s vs 3.36 ± 0.33 s, * P < 0.05, ANOVA).

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