This overlap is highly significant, since observing an overlap of 72 or more probes between the two enlarged signatures with the smallest number of genes (164 genes, enlarged Invasiveness Gene Signature; and 189 genes, enlarged Gene expression Grade Index signature) is already highly significant ( P <2.2 × 10 -16 , hypergeometric test).
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A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer.
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