APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA.

Retrovirology · 2009 · PMC2657108 · PMID 19216784

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hedged sentence

0.0038

closest p · 0.1× alpha

0.0038

boldest claim

The sentences

highly significantP = 0.0038actually significant

The differences in the G-to-A mutation frequency between viral DNA and cRNA were highly significant ( P = 0.0038 and P = 0.0139 for Rounds 2 and 3, respectively; Student's t -test).

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